Which drug is a potassium-sparing diuretic?

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Multiple Choice

Which drug is a potassium-sparing diuretic?

Explanation:
Potassium-sparing diuretics work by blocking aldosterone’s action in the late distal tubule and collecting duct, which reduces sodium reabsorption and potassium loss. Spironolactone fits this description because it is an aldosterone (mineralocorticoid receptor) antagonist, so it promotes sodium excretion while conserving potassium. This contrasts with loop diuretics (furosemide, bumetanide) and thiazides (hydrochlorothiazide), which increase potassium excretion and are not potassium-sparing.

Potassium-sparing diuretics work by blocking aldosterone’s action in the late distal tubule and collecting duct, which reduces sodium reabsorption and potassium loss. Spironolactone fits this description because it is an aldosterone (mineralocorticoid receptor) antagonist, so it promotes sodium excretion while conserving potassium. This contrasts with loop diuretics (furosemide, bumetanide) and thiazides (hydrochlorothiazide), which increase potassium excretion and are not potassium-sparing.

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