Which antihistamine is listed for allergies and should avoid alcohol?

• A. Diphenhydramine (Benadryl)
• B. Loratadine
• C. Fexofenadine
• D. Cetirizine

Answer: (A)

The main idea is the interaction between certain antihistamines and alcohol. Diphenhydramine is a first-generation antihistamine that readily crosses into the brain, causing significant drowsiness and cognitive effects. Alcohol also depresses the central nervous system, so combining it with diphenhydramine greatly increases the risk of extreme sedation, confusion, and impaired functioning—outcomes particularly concerning for older adults who are more sensitive to these effects. This is why alcohol avoidance is emphasized with this medication.

The other options are newer, second-generation antihistamines that are designed to be much less sedating. Because they cause less central nervous system depression, they typically do not carry the same strong warning to avoid alcohol. They may still cause some mild drowsiness in some people, but the risk profile is not as pronounced as with diphenhydramine.